This is key, have the option to filter using "not equal" condition inside the segments, for example to do a newsletter based on the city, right now you can have all the customers from a city but you cant have the ones outside that city, so its not possible to do a tailored newsletter

This is an essential segmentation option. The current implementation is incomplete without it.

We need any sort of exclusion logic that's possible. Examples:

• Everyone those on List B;

• Everyone, but those who were sent email XY (whether they opened it or not).

The current logic available is rudimentary and insufficient. Look at MailChimp for inspiration.